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National Center for Research Resources (NCRR)
http://www.ncrr.nih.gov/

The National Center for Research Resources (NCRR) provides laboratory scientists and clinical researchers with environments and tools that they can use to prevent, detect, and treat a wide range of diseases. This support enables discoveries that begin at the molecular and cellular level, move to animal-based studies, and then are translated to patient-oriented clinical research, resulting in cures and treatments for both common and rare diseases. NCRR connects researchers with patients and communities across the nation to bring the power of shared resources and research to improve human health.

NCRR supports nutrition-related research primarily through the Institutional Development Award (IDeA), the General Clinical Research Centers (GCRCs), and the Research Centers in Minority Institutions (RCMI) programs.  The IDeA program fosters health-related research and enhances the competitiveness of investigators by supporting faculty development and research infrastructure enhancement at institutions located in states in which the aggregate NIH funding has historically been low, and also serves unique populations—such as rural and medically underserved communities—in those 23 states and Puerto Rico.  The GCRC program, which is transforming to the Clinical and Translational Science Award program, offers clinical investigators specialized research environments that provide the infrastructure necessary to conduct patient-oriented research.  The RCMI program is dedicated to enhancing research capability in minority institutions that have doctoral programs in the health sciences. The RCMI Infrastructure for Clinical and Translational Research (RCTR) awards support the development of infrastructure required for the conduct of clinical and translational research in institutions funded via the RCMI program. This program was developed to improve collaboration and coordination of clinical and translational research programs within RCMI institutions and to foster collaborations and partnerships with other institutions.  In addition, NCRR supports the development of animal models to facilitate the translation of laboratory findings to clinical trials through the National Primate Research Centers (NPRCs).

Research Directions

The following are examples of NCRR's nutrition-related research support:

Pediatric

  • Calcium Absorption in Neonates Fed with Mother's Milk Fortified with a Donor
  • Vitamin D Status and Impact on Bone Mineralization in Human Milk Fed Hispanic
  • Identifying Vitamin D Deficiency & Effect in Very Low Birth Weight Infants
  • Zinc and Copper Excretion and Absorption in Infants with Ostomies
  • Evaluation of Calcium, Vitamin D, Magnesium and Zinc Absorption in Healthy
  • Evaluation of the Use of Donor Human Milk for Infants with Abdominal Wall Defect
  • Effects of Growth Hormone Therapy on Glucose and Protein Metabolism in Children
  • Absorpt, Retent &  Long-Term Impact of Vitamin A Supplements In Zambian Children
  • Protein and Energy Use in Pediatric Crohn's Disease
  • Dyslipidemia and CV Risk Factors In Pediatric Obesity and Type 2 Diabetes
  • Nutritional Management of Infants with Bronchopulmonary Dysplasia (BPD): EFFE
  • Impact of Total Body Fat in Sedentary Hispanic Adolescents with Normal BMI

Maternal Nutrition

  • The Role of Dietary Carbohydrate on Maternal Fat Mobilization and Oxidation
  • Maternal and Dietary Factors Associated with Iron Deficiency Anemia in Infancy
  • The Role of Protein Malnutrition on Circadian Physiology Of C57bl/6j Mouse Dams
  • Maternal Diet Modifies the Fetal Primate Epigenome and Circadian Gene Expression
  • Maternal High Fat Diet and the Melanocortin System in the Offspring
  • Maternal High Fat Diet Programs Vascular Pathology in Infants
  • Impact of Maternal Obesity and Dietary Excess on Fetal Adiposity

Animal models

  • A Rodent Model to Study Links among Diet, Visceral Adipose and Cardiomyopathy
  • Caloric Restriction and Aging in Nonhuman Primate Eyes
  • Maternal Hyperinsulinemia and Fetal Programming
  • Obese Nonhuman Primate Resource
  • A Nonhuman Primate Model for the Link between Childhood Asthma & Obesity
  • Dietary Restriction and Aging
  • Hypothalamic Deep Brain Stimulation for Morbid Obesity: Development of a Pig Model
  • Resource for Rat Genetic Models of Aerobic Capacity
  • Developmental Programming, Maternal Obesity and Overnutrition

Obesity

  • Financial Incentives to Promote Physical Activity in Sedentary, Overweight
  • Effect of Pre and Postnatal Nutritional Programming on Scd1 Activity and Obesity
  • Fructose Levels after Soft Drink Challenge in Teenagers with Obesity and Diabetes
  • PACEI- PC Primary Care Management Of Adolescent Obesity
  • Mexican American Obese Children Study
  • Obesity among Inner City Latino Children and Adolescents: Intervention Project
  • Yup'ik Perceptions of Body Weight and Diabetes
  • Mechanisms for Differential Effects of Dietary Fatty Acids on Metabolism
  • Adolescents Committed To Improvement of Nutrition and Physical Activity (ACTION)
  • Fitfamily: A Nutrition, Fitness and Wellness Program to Prevent and Manage Obesity in Children and Adolescents
  • Magnesium Supplements, Plasma Inflammatory Markers, and Gene Expression in Overweight Individuals W/ Metabolic Syndrome

Diet

  • Clinical Trial: Dietary Macronutrient Intake and Exercise on Glucose and Insulin
  • Contaminants and Nutrients in Alaskan Subsistence Foods: Striking a Balance
  • Validation of Web-Based Multimedia Dietary Assessment Tools
  • Impact of Dietary Calcium and Oxalate Ratios, and Oxalobacter Formigenes Colonization of Urinary Oxalate
  • Nutrition and Physical Activity
  • Developing a Novel Set Of Diet Pattern Biomarkers
  • Mechanisms Of Aging-Induced Leptin Resistance And Obesity
  • Endocrine and Nutritional Control of Long Bone Growth
  • Fitness and Nutrition Core Facility

Metabolism

  • Maltase-Glucoamylase:  Regulator of Starch Digestion
  • Selenium Rich Lentils: a Whole Food Solution for Improved Human Health?
  • Vitamin D Supplementation and Muscle Function -CRU Pilot Study
  • Assessment of Vitamin B12 Bioavailability from Egg
  • Enzymes of Thiamin Metabolism
  • Vitamin D Study
  • Clinical Trial: Vitamin D Pilot (RTRN)
  • Dietary Methionine Uptake by Splanchnic Region in Healthy and Sick Children

AIDS

  • The Altered Protein Metabolism of Pediatric Patients with HIV Infection
  • Diet/Exercise, Niacin, Fenofibrate for HIV Lipodystrophy
  • The Altered Lipid And Protein Metabolism Of Pediatric Patients With HIV Infection
  • The Effect of Leptin Therapy on Lipid Metabolism in HIV-Lipodystrophy
  • Adolescent Master Protocol (AMP) - Impact of HIV and ART on Growth
  • Evaluation of High-Protein Supplementation in Weight-Stable HIV-Positive

Cardiovascular Disease

  • Macronutrient Composition of Diet and Risk Factors for Cardiovascular Disease
  • D1, AT1 Receptors in Human Hypertension: Sodium Sensitivity Of Blood Pressure
  • Mechanisms Underlying Sodium Intake Mediated Vascular Function
  • Diet, Immunodeficiency-Virus Infection, and Cardiovascular Risk
  • Maternal Consumption of A Western Diet Promotes Obesity and Hypertension in Offspring

Cancer

  • Vitamin D & Soy for Biochemically Recurrent Prostate Cancer
  • Anticancer Mechanisms of Lycopene Action
  • Investigation of Reishi as a Natural Therapeutic for Inflammatory Breast Cancer
  • Clinical trial: The Selenium and Vitamin E Chemoprevention Trial (SELECT)
  • Studies on the Anti-Breast Cancer Function of Bamboo Extract
  • Low-Fat Diet and Omega-Fatty Acids for Prostate Cancer Prevention
  • Diet, Genetic Expression and Clinical Outcomes in Prostate Cancer

Nutrition and Other Diseases

  • Effects of Dietary Selenium on the Development of Asthma
  • Pilot Study: Role of Dietary Fiber in PCOS  Anovulation
  • Clinical Trial: Omega-3 Fatty Acids for Treatment of Major Depression: Different
  • Improving Control with Activity and Nutrition (Diabetes)
  • Randomized, Placebo-Controlled Trial of Oral Calcium Supplementation for Osteopenia in Girls and Women with Rett Syndrome
  • Pilot, Randomized, Double-Blind, Crossover Study of Fish Oil [EPA and DHA for Intractable Partial Seizures]
  • Dietary Supplement for Managing Nutritional Deficiencies in Sickle Cell Disease
  • Zinc Treatment to Reduce Duration of Diarrhea

Nutrition Education

  • Patient Oriented Research in Clinical Nutrition
  • West Virginia HSTA Students Design Public Health Clinical Trials
  • Epidemiology and the Energy Balance Equation

The NCRR will continue to support resources essential to the conduct of biomedical research which will lead to improved human health.

For more information on the NCRR nutrition program, contact:

Krishan K. Arora, Ph.D.
Health Scientist Administrator
Division of Research Infrastructure
National Center for Research Resources
National Institutes of Health
6701 Democracy Boulevard, Room 938
Bethesda, MD 20892-4874
Phone:  301-435-0760
FAX: 301-480-3770
E-mail: arorak@mail.nih.gov

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This page last reviewed: February 17, 2011

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